MafB Maintains <i>β</i>-Cell Identity under MafA-Deficient Conditions.

ABSTRACT: The transcription factor MafB plays an essential role in β-cell differentiation during the embryonic stage in rodents. Although MafB disappears from β-cells after birth, it has been reported that MafB can be evoked in β-cells and is involved in insulin⁺β-cell number and islet architecture maintenance in adult mice under diabetic conditions. However, the underlying mechanism by which MafB protects β-cells remains unknown. To elucidate this, we performed RNA sequencing using an inducible diabetes model (A0B^Δpanc mice) that we previously generated. We found that the deletion of Mafb can induce β-cell dedifferentiation, characterized by the upregulation of dedifferentiation markers, Slc5a10 and Cck, as

SUBMITTER: Deng Z 

PROVIDER: S-EPMC9387222 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature