Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse.
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ABSTRACT:
SUBMITTER: Gendy MNS
PROVIDER: S-EPMC9387363 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse.
Gendy Marie N S MNS Zai Clement C Le Foll Bernard B Kennedy James L JL
The Canadian journal of addiction 20191201 4
Alcohol use disorder is a complex disorder that is influenced by genetic factors. The non-synonymous single-nucleotide polymorphism (SNP) rs1799971 in exon 1 in opioid receptor <i>OPRM1</i> was extensively studied in patients with alcohol dependence with mixed findings. Moreover, studies showed that opioid receptor polymorphism might play a role in the pathophysiology of schizophrenia. Our results suggest that rs1799971 SNP is not significantly associated with alcohol dependence in our sample of ...[more]
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