Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment.

ABSTRACT: A single biomarker is not adequate to identify patients with gastric cancer (GC) who have the potential to benefit from anti-PD-1/PD-L1 therapy, presumably owing to the complexity of the tumour microenvironment. The predictive value of tumour-infiltrating immune cells (TIICs) has not been definitively established with regard to their density and spatial organisation. Here, multiplex immunohistochemistry is used to quantify in situ biomarkers at sub-cellular resolution in 80 patients with GC. To predict the response to immunotherapy, we establish a multi-dimensional TIIC signature by considering the density of CD4⁺FoxP3^-PD-L1⁺, CD8⁺PD-1^-LAG3^-, and CD68⁺STING⁺ cells and the spatial organisation of CD8

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9388563 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature