Development and validation of a risk score for predicting clinical success after endobiliary stenting for malignant biliary obstruction.

ABSTRACT:

Background

Endoscopic drainage is the primary treatment for unresectable malignant biliary obstruction (MBO). This study developed and validated a pre-endoscopic predictive score for clinical success after stent placement.

Methods

Patients with unresectable MBO undergoing ERCP-guided endobiliary stent placement between 2007 and 2017 were randomly divided into derivation (n = 383) and validation (n = 128) cohorts. To develop the risk score, clinical parameters were built by logistic regression to predict (1) ≥ 50% total bilirubin (TB) resolution within 2 weeks and (2) bilirubin normalization (TB level <1.2 mg/dL) within 6 weeks following stenting. The scoring scheme was applied to the validation cohort to test its performance.

Results

A ≥ 50% TB resolution within 2 wee

SUBMITTER: Pausawasdi N 

PROVIDER: S-EPMC9390920 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature