ANRIL regulates multiple molecules of pathogenetic significance in diabetic nephropathy.

ABSTRACT:

Background

Hyperglycemia-induced transcriptional alterations lead to aberrant synthesis of a large number of pathogenetic molecules leading to functional and structural damage to multiple end organs including the kidneys. Diabetic nephropathy (DN) remains a major cause of end stage renal disease. Multiple epigenetic mechanisms, including alteration of long non-coding RNAs (lncRNAs) may play a significant role mediating the cellular transcriptional activities. We have previously shown that lncRNA ANRIL may mediate diabetes associated molecular, functional and structural abnormalities in DN. Here we explored downstream mechanisms of ANRIL alteration in DN.

Methods

We used renal cortical tissues from ANRIL knockout (KO) mice and wild type (WT) mice, with or without streptozotoc

SUBMITTER: Sooshtari P 

PROVIDER: S-EPMC9390929 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature