Quantification of very late xerostomia in head and neck cancer patients after irradiation.

ABSTRACT:

Objective

Radiation therapy (RT) for head and neck cancer (HNC) can result in severe xerostomia, or the subjective feeling of dry mouth. Characterizing xerostomia is critical to designing future clinical trials investigating how to improve HNC patients' quality of life (QoL). Few studies have investigated the very late (>5 years post-RT) effects of RT for HNC. We undertook preliminary studies quantifying very late xerostomia.

Methods

Six adults who underwent RT for HNC at least 5 years prior and reported xerostomia were enrolled. Five healthy adults without a self-reported history of HNC or xerostomia were enrolled as controls. All participants completed three validated surveys to measure xerostomia-related QoL. Salivary production rates were measured and compositional analy

SUBMITTER: Blitzer GC 

PROVIDER: S-EPMC9392383 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature