New KCNN4 Variants Associated With Anemia: Stomatocytosis Without Erythrocyte Dehydration.

ABSTRACT: The K⁺ channel activated by the Ca²⁺, KCNN4, has been shown to contribute to red blood cell dehydration in the rare hereditary hemolytic anemia, the dehydrated hereditary stomatocytosis. We report two de novo mutations on KCNN4, We reported two de novo mutations on KCNN4, V222L and H340N, characterized at the molecular, cellular and clinical levels. Whereas both mutations were shown to increase the calcium sensitivity of the K⁺ channel, leading to channel opening for lower calcium concentrations compared to WT KCNN4 channel, there was no obvious red blood cell dehydration in patients carrying one or the other mutation. The clinical phenotype was greatly different between carriers of the mutated gene ranging from severe anemia for

SUBMITTER: Allegrini B 

PROVIDER: S-EPMC9393219 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature