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Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine.


ABSTRACT: Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated delirium via the gut-brain axis remains unknown. Leveraging a mouse model of foot incision-induced surgical pain and delirium-like behavior, we found that electroacupuncture stimulation at specific acupoints (e.g., DU20+KI1) attenuated both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision-induced surgical pain and delirium-like behavior showed gut microbiota imbalance, microglia activation in the spinal cord, somatosensory cortex, and hippocampus, as well as an enhanced dendritic spine elimination in cortex revealed by two-photon imaging. The electroacupuncture regimen that alleviated surgical pain and delirium-like behavior in mice also effectively restored the gut microbiota balance, prevented the microglia activation, and reversed the dendritic spine elimination. These data demonstrated a potentially important gut-brain interactive mechanism underlying the surgical pain-induced delirium in mice. Pending further studies, these findings revealed a possible therapeutic approach in preventing and/or treating postoperative delirium by using perioperative electroacupuncture stimulation in patients.

SUBMITTER: Yang L 

PROVIDER: S-EPMC9393710 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice <i>via</i> remodeling gut microbiota and dendritic spine.

Yang Liuyue L   Ding Weihua W   Dong Yuanlin Y   Chen Cynthia C   Zeng Yanru Y   Jiang Zhangjie Z   Gan Shuyuan S   You Zerong Z   Zhao Yilin Y   Zhang Yiying Y   Ren Xinghua X   Wang Shiyu S   Dai Jiajia J   Chen Zhong Z   Zhu Shengmei S   Chen Lucy L   Shen Shiqian S   Mao Jianren J   Xie Zhongcong Z  

Frontiers in immunology 20220808


Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated delirium <i>via</i> the gut-brain axis remains unknown. Leveraging a mouse model of foot incision-induced surgical pain and delirium-like behavior, we found that electroacupuncture stimulation at specific acupoints (e.g., DU20+KI1) attenuated both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision-  ...[more]

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