Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC9393710 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Yang Liuyue L Ding Weihua W Dong Yuanlin Y Chen Cynthia C Zeng Yanru Y Jiang Zhangjie Z Gan Shuyuan S You Zerong Z Zhao Yilin Y Zhang Yiying Y Ren Xinghua X Wang Shiyu S Dai Jiajia J Chen Zhong Z Zhu Shengmei S Chen Lucy L Shen Shiqian S Mao Jianren J Xie Zhongcong Z
Frontiers in immunology 20220808
Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated delirium <i>via</i> the gut-brain axis remains unknown. Leveraging a mouse model of foot incision-induced surgical pain and delirium-like behavior, we found that electroacupuncture stimulation at specific acupoints (e.g., DU20+KI1) attenuated both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision- ...[more]