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Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation.

ABSTRACT:

SUBMITTER: Ruane PT

PROVIDER: S-EPMC9398450 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation.

Ruane Peter T PT Garner Terence T Parsons Lydia L Babbington Phoebe A PA Wangsaputra Ivan I Kimber Susan J SJ Stevens Adam A Westwood Melissa M Brison Daniel R DR Aplin John D JD

Human reproduction (Oxford, England) 20220401 4

<h4>Study question</h4>How does the human embryo breach the endometrial epithelium at implantation?<h4>Summary answer</h4>Embryo attachment to the endometrial epithelium promotes the formation of multinuclear syncytiotrophoblast from trophectoderm, which goes on to breach the epithelial layer.<h4>What is known already</h4>A significant proportion of natural conceptions and assisted reproduction treatments fail due to unsuccessful implantation. The trophectoderm lineage of the embryo attaches to ...[more]

PMID: 35079788

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