Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation.

ABSTRACT:

Background

T cell activation leads to increased expression of the receptor for the iron transporter transferrin (TfR) to provide iron required for the cell differentiation and clonal expansion that takes place during the days after encounter with a cognate antigen. However, T cells mobilise TfR to their surface within minutes after activation, although the reason and mechanism driving this process remain unclear.

Results

Here we show that T cells transiently increase endocytic uptake and recycling of TfR upon activation, thereby boosting their capacity to import iron. We demonstrate that increased TfR recycling is powered by a fast endocytic sorting pathway relying on the membrane proteins flotillins, Rab5- and Rab11a-positive endosomes. Our data further reveal that iron imp

SUBMITTER: Rossatti P 

PROVIDER: S-EPMC9400314 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature