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The impact of tumour pH on cancer progression: strategies for clinical intervention.

ABSTRACT: Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H⁺-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets.

SUBMITTER: Ward C

PROVIDER: S-EPMC9400736 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The impact of tumour pH on cancer progression: strategies for clinical intervention.

Ward Carol C Meehan James J Gray Mark E ME Murray Alan F AF Argyle David J DJ Kunkler Ian H IH Langdon Simon P SP

Exploration of targeted anti-tumor therapy 20200428 2

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H<sup>+</sup>-ATPase proton ...[more]

PMID: 36046070

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