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Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization.

ABSTRACT: A Ru(bpy)₃ Cl₂ photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.

SUBMITTER: Watson EE

PROVIDER: S-EPMC9400970 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization.

Watson Emma E EE Russo Francesco F Moreau Dimitri D Winssinger Nicolas N

Angewandte Chemie (International ed. in English) 20220520 28

A Ru(bpy)<sub>3</sub> Cl<sub>2</sub> photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics. ...[more]

PMID: 35510306

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