Transcriptome-wide association study of HIV-1 acquisition identifies <i>HERC1</i> as a susceptibility gene.

ABSTRACT: The host genetic factors conferring protection against HIV type 1 (HIV-1) acquisition remain elusive, and in particular the contributions of common genetic variants. Here, we performed the largest genome-wide association meta-analysis of HIV-1 acquisition, which included 7,303 HIV-1-positive individuals and 587,343 population controls. We identified 25 independent genetic loci with suggestive association, of which one was genome-wide significant within the major histocompatibility complex (MHC) locus. After exclusion of the MHC signal, linkage disequilibrium score regression analyses revealed a SNP heritability of 21% and genetic correlations with behavioral factors. A transcriptome-wide association study identified 15 susceptibility genes, including HERC1, UEVLD, and HIST

SUBMITTER: Duarte RRR 

PROVIDER: S-EPMC9403347 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature