ON donor tethered copper (II) and vanadium (V) complexes as efficacious anti-TB and anti-fungal agents with spectroscopic approached HSA interactions.

ABSTRACT: Antimicrobial drug resistance poses a significant threat worldwide, hence triggering an urgent situation for developing feasible drugs. 3D-transition metal coordination complexes being multifaceted, offer tremendous potency as drug candidates. However, there are fewer reports on non-toxic and safe transition metal complexes; therefore, we hereby attempted to develop novel copper and vanadium-based therapeutic agents. We have synthesised six metal complexes viz., [V^VO₂(Quibal-INH)] (1), [Cu^II(Quibal-INH)₂] (2), [V^VO(Quibal-INH) (cat)] (3), [Cu^II(Quibal-INH) (cat)] (4), [V^VO(Quibal-INH) (bha)] (5) and [Cu^II(Quibal-INH) (bha)] (6). Quibal-INH (L) is a

SUBMITTER: Sinha A 

PROVIDER: S-EPMC9403362 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature