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BF₃·Et₂O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides.

ABSTRACT: Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF₃·Et₂O. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides via an annulation and dehydration process.

SUBMITTER: Cheng Z

PROVIDER: S-EPMC9404108 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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BF3·Et2O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides.

Cheng Zhenfeng Z Gu Qingyun Q Xie Yushan Y Zhang Yanan Y Zeng Xiaobao X

RSC advances 20220825 37

Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF3·Et2O. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides via an annulation and dehydration process. ...[more]

PMID: 36128547

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