Catalytic Synthesis of 5-Fluoro-2-oxazolines: Using BF₃·Et₂O as the Fluorine Source and Activating Reagent.

ABSTRACT: Hypervalent iodine catalyst-catalyzed nucleophilic fluorination of unsaturated amides using BF₃·Et₂O as the fluorine source and activating reagent was reported. Various 5-fluoro-2-oxazoline derivatives were synthesized in good to excellent yields (up to 95% isolated yield) within 10 min. The process was efficient and metal-free under mild conditions. A mechanism involving a fluorination/1,2-aryl migration/cyclization cascade was proposed on the basis of previous work and experimental results.

SUBMITTER: Chai H 

PROVIDER: S-EPMC9202255 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature