Whole genome sequencing for tuberculosis in Victoria, Australia: A genomic implementation study from 2017 to 2020

ABSTRACT: Summary

Background

Whole genome sequencing (WGS) is increasingly used by tuberculosis (TB) programs to monitor Mycobacterium tuberculosis (Mtb) transmission. We aimed to characterise the molecular epidemiology of TB and Mtb transmission in the low-incidence setting of Victoria, Australia, and assess the utility of WGS.

Methods

WGS was performed on all first Mtb isolates from TB cases from 2017 to 2020. Potential clusters (≤12 single nucleotide polymorphisms [SNPs]) were investigated for epidemiological links. Transmission events in highly-related (≤5 SNPs) clusters were classified as likely or possible, based on the presence or absence of an epidemiological link, respectively. Case characteristics and transmission settings (as defined by case relationship) were summarised

SUBMITTER: Dale K 

PROVIDER: S-EPMC9405109 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature