Multi-site implementation of whole genome sequencing for hospital infection control: A prospective genomic epidemiological analysis.

ABSTRACT:

Background

Current microbiological methods lack the resolution to accurately identify multidrug-resistant organism (MDRO) transmission, however, whole genome sequencing can identify highly-related patient isolates providing opportunities for precision infection control interventions. We investigated the feasibility and potential impact of a prospective multi-centre genomics workflow for hospital infection control.

Methods

We conducted a prospective genomics implementation study across eight Australian hospitals over 15 months (2017,2018), collecting all clinical and screening isolates from inpatients with vanA VRE, MRSA, ESBL Escherichia coli (ESBL-Ec), or ESBL Klebsiella pneumoniae (ESBL-Kp). Genomic and epidemiologic data were integrated to assess MDRO

SUBMITTER: Sherry NL 

PROVIDER: S-EPMC9019234 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature