Mechanical Unloading of the Left Ventricle before Coronary Reperfusion in Preclinical Models of Myocardial Infarction without Cardiogenic Shock: A Meta-Analysis.

ABSTRACT:

Aim

to compare a conventional primary reperfusion strategy with a primary unloading approach before reperfusion in preclinical studies.

Methods

we performed a meta-analysis of preclinical studies. The primary endpoint was infarct size (IS). Secondary endpoints were left ventricle end-diastolic pressure (LVEDP), mean arterial pressure (MAP), heart rate (HR), cardiac output (CO). We calculated mean differences (MDs) and associated 95% confidence intervals (CIs). Sensitivity and subgroup analyses on the primary and secondary endpoints, as well as a meta-regression on the primary endpoint using the year of publication as a covariate, were also conducted.

Results

11 studies (n = 142) were selected and entered in the meta-analysis. Primary unloading reduced IS (MD -2

SUBMITTER: Benenati S 

PROVIDER: S-EPMC9409839 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature