Cellular taxonomy of Hic1⁺ mesenchymal progenitor derivatives in the limb: from embryo to adult.

ABSTRACT: Tissue development and regeneration rely on the cooperation of multiple mesenchymal progenitor (MP) subpopulations. We recently identified Hic1 as a marker of quiescent MPs in multiple adult tissues. Here, we describe the embryonic origin of appendicular Hic1⁺ MPs and demonstrate that they arise in the hypaxial somite, and migrate into the developing limb at embryonic day 11.5, well after limb bud initiation. Time-resolved single-cell-omics analyses coupled with lineage tracing reveal that Hic1⁺ cells generate a unique MP hierarchy, that includes both recently identified adult universal fibroblast populations (Dpt⁺, Pi16⁺ and Dpt⁺ Col15a1⁺) and more specialised mesenchymal derivatives such as, peri and endoneurial cells, per

SUBMITTER: Arostegui M 

PROVIDER: S-EPMC9411605 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature