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Searching for methyllysine-binding aromatic cages.

ABSTRACT: Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated with methylation of non-histone proteins, particularly in the cytoplasm of the cell, are not well understood. Here, we describe a search for potential methyllysine readers using a rapid structural motif-mining algorithm Erebus, the PDB database, and knowledge of the methyllysine binding mechanisms.

SUBMITTER: Vann KR

PROVIDER: S-EPMC9416871 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Searching for methyllysine-binding aromatic cages.

Vann Kendra R KR Vishweshwaraiah Yashavantha L YL Dokholyan Nikolay V NV Kutateladze Tatiana G TG

The Biochemical journal 20211001 19

Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated with methylation of non-histone proteins, particularly in the cytoplasm of the cell, are not well understood. Here, we describe a search for potential methyllysine readers using a rapid structural motif-mining algorithm Erebus, the PDB database, an ...[more]

PMID: 34624071

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