Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study.

ABSTRACT: Acute respiratory distress syndrome is a heterogeneous pathophysiological process responsible for significant morbidity and mortality in pediatric intensive care patients. Diagnosis is defined by clinical characteristics that identify the syndrome after development. Subphenotyping patients at risk of progression to ARDS could provide the opportunity for therapeutic intervention. microRNAs, non-coding RNAs stable in circulation, are a promising biomarker candidate. We conducted a single-center prospective cohort study to evaluate random forest classification of microarray-quantified circulating microRNAs in critically ill pediatric patients. We additionally selected a sub-cohort for parallel metabolomics profiling as a pilot study for concurrent use of miRNAs and metabolites as circulating

SUBMITTER: Ohlstrom DJ 

PROVIDER: S-EPMC9418138 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature