Assessing size-dependent cytotoxicity of boron nitride nanotubes using a novel cardiomyocyte AFM assay.

ABSTRACT: As boron nitride nanotubes (BNNTs) find increased use in numerous applications, potential adverse health effects of BNNT exposure are a growing concern. Current in vitro cytotoxicity studies on BNNTs are inconsistent and even contradictory, likely due to the lack of reference materials, standardized characterization methods and measurement protocols. New approaches, particularly with the potential to reliably relate in vitro to in vivo studies, are critically needed. This work introduces a novel atomic force microscopy (AFM)-based cardiomyocyte assay that reliably assesses the cytotoxicity of a well-characterized boron nitride nanotube reference material, code named BNNT-1. High energy probe sonication was used to modify and control the length of BNNT-1. The polymer po

SUBMITTER: Augustine J 

PROVIDER: S-EPMC9418822 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature