Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility.

ABSTRACT:

Background

The ACE2 protein acts as a gateway for SARS-CoV-2 in the host cell, playing an essential role in susceptibility to infection by this virus. Genetics and epigenetic mechanisms related to the ACE2 gene are associated with changes in its expression and, therefore, linked to increased susceptibility to infection. Although some variables such as sex, age, and obesity have been described as risk factors for COVID-19, the molecular causes involved in the disease susceptibility are still unknown.

Aim

To evaluate the ACE2 gene expression profiles and their association with epigenetic mechanisms and demographic or clinical variables.

Methods

In 500 adult volunteers, the mRNA expression levels of the ACE2 gene in nasopharyngeal swab samples and its methylation status

SUBMITTER: Daniel G 

PROVIDER: S-EPMC9420046 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature