Is rosuvastatin protective against sepsis-associated encephalopathy? A secondary analysis of the SAILS trial.

ABSTRACT:

Background

Sepsis is a common cause of death in emergency departments and sepsis-associated encephalopathy (SAE) is a major complication. Rosuvastatin may play a neuroprotective role due to its protective effects on the vascular endothelium and its anti-inflammatory functions. Our study aimed to explore the potential protective function of rosuvastatin against SAE.

Methods

Sepsis patients without any neurological dysfunction on admission were prospectively enrolled in the "Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome" study (SAILS trial, ClinicalTrials.gov number: NCT00979121). Patients were divided into rosuvastatin and placebo groups. This is a secondary analysis of the SAILS dataset. Baseline characteristics, therapy outcomes, and adverse drug ev

SUBMITTER: Yu SY 

PROVIDER: S-EPMC9420670 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature