ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors.

ABSTRACT:

Background

Common genetic variation in close proximity to the ILRUN gene are significantly associated with coronary artery disease as well as with plasma lipid traits. We recently demonstrated that hepatic inflammation and lipid regulator with ubiquitin-associated domain-like and NBR1-like domains (ILRUN) regulates lipoprotein metabolism in vivo in mice. However, whether ILRUN, which is expressed in vascular cells, directly impacts atherogenesis remains unclear. We sought to determine the role of ILRUN in atherosclerosis development in mice.

Methods

For our study, we generated global Ilrun-deficient (IlrunKO) male and female mice on 2 hyperlipidemic backgrounds: low density lipoprotein receptor knockout (LdlrKO) and apolipoprotein E knockout (A

SUBMITTER: Bi X 

PROVIDER: S-EPMC9420832 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature