Irritable bowel syndrome in women: Association between decreased insular subregion volumes and gastrointestinal symptoms.

ABSTRACT:

Objective

Irritable bowel syndrome (IBS) is a chronic pain disorder characterized by disturbed interactions between the gut and the brain with depression as a common comorbidity. In both IBS and depression, structural brain alterations of the insular cortices, key structures for pain processing and interoception, have been demonstrated but the specificity of these findings remains unclear. We compared the gray matter volume (GMV) of insular cortex (IC) subregions in IBS women and healthy controls (HC) and examined relations to gastrointestinal (GI) symptoms and glutamate + glutamine (Glx) concentrations. We further analyzed GMV of IC subregions in women with major depression (MDD) compared to HC and addressed possible differences between depression, IBS, IBS with depression and HC.

SUBMITTER: Barazanji N 

PROVIDER: S-EPMC9421502 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature