Impact of alcohol-induced intestinal microbiota dysbiosis in a rodent model of Alzheimer's disease.

ABSTRACT: Introduction: Alzheimer's disease (AD) is a devastating neurodegenerative disorder. While genetics are important in the development of AD, environment and lifestyle are also important factors influencing AD. One such lifestyle factor is alcohol consumption. Unhealthy and excessive chronic alcohol consumption is associated with a greater risk of all types of dementia, especially AD. Alcohol consumption has numerous effects on the body, including alterations to the intestinal microbiota (dysbiosis) and intestinal barrier dysfunction (leakiness and intestinal hyperpermeability), with evidence indicating that inflammation resulting from dysbiosis and barrier dysfunction can promote neuroinflammation impacting brain structure and function. Objective: This study sought to determine

SUBMITTER: Frausto DM 

PROVIDER: S-EPMC9421609 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature