Multi-target action of β-alanine protects cerebellar tissue from ischemic damage.
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ABSTRACT:
SUBMITTER: Kopach O
PROVIDER: S-EPMC9424312 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
Multi-target action of β-alanine protects cerebellar tissue from ischemic damage.
Kopach Olga O Rusakov Dmitri A DA Sylantyev Sergiy S
Cell death & disease 20220829 8
Brain ischemic stroke is among the leading causes of death and long-term disability. New treatments that alleviate brain cell damage until blood supply is restored are urgently required. The emerging focus of anti-stroke strategies has been on blood-brain-barrier permeable drugs that exhibit multiple sites of action. Here, we combine single-cell electrophysiology with live-cell imaging to find that β-Alanine (β-Ala) protects key physiological functions of brain cells that are exposed to acute st ...[more]
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