Deconvolution of B cell receptor repertoire in multiple sclerosis patients revealed a delay in tBreg maturation.

ABSTRACT:

Background

B lymphocytes play a pivotal regulatory role in the development of the immune response. It was previously shown that deficiency in B regulatory cells (Bregs) or a decrease in their anti-inflammatory activity can lead to immunological dysfunctions. However, the exact mechanisms of Bregs development and functioning are only partially resolved. For instance, only a little is known about the structure of their B cell receptor (BCR) repertoires in autoimmune disorders, including multiple sclerosis (MS), a severe neuroinflammatory disease with a yet unknown etiology. Here, we elucidate specific properties of B regulatory cells in MS.

Methods

We performed a prospective study of the transitional Breg (tBreg) subpopulations with the CD19⁺CD24^highCD38<

SUBMITTER: Lomakin YA 

PROVIDER: S-EPMC9425031 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature