Risk HLA Variants Affect the T-Cell Repertoire in Multiple Sclerosis.

ABSTRACT:

Background and objectives

The major histocompatibility complex (MHC) locus has a predominant role in the genetic predisposition to multiple sclerosis (MS), with 32 associations found to be involved. We aimed to investigate the impact of MHC MS-risk alleles on T-cell repertoire in patients with MS.

Methods

We studied 161 untreated patients with relapsing-remitting MS for whom Class I and II human leukocyte antigen (HLA) alleles were inferred from whole-genome genotyping data, and T-cell receptor (TCR) CDR3 sequences were obtained through next-generation sequencing. T-cell repertoire features including diversity, public clones, and architecture were evaluated.

Results

We identified 5 MS-risk loci associated with TCR diversity: HLA-DRB1*15:01 (7.65 × 10^-3), rs

SUBMITTER: Sorosina M 

PROVIDER: S-EPMC9931183 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature