Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants.

ABSTRACT:

Background

The host immune system plays an important role in hepatitis B virus (HBV) infection manifestation. Genetic polymorphisms of several inflammatory cytokines, including TNF-α and IL-10, have been associated with chronic hepatitis B (CHB) progression, although with contradicting results. CHB progression can be categorized into four phases, immune tolerance (IT), immune clearance (IC), low/no replicative (LR), and e-negative hepatitis (ENH), with HBeAg seroconversion as an important milestone. Here, we determined the association of TNF-α (rs1800629) and IL-10 (rs1800896 and rs1800872) SNPs in the context of CHB natural history progression, particularly to HBeAg seroconversion, in Indonesian CHB patients.

Methods

A total of 287 subjects were recruited and

SUBMITTER: Turyadi 

PROVIDER: S-EPMC9427277 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature