Phylogenetic analysis of the emergence of main hepatitis C virus subtypes in Sao Paulo, Brazil.

ABSTRACT:

Background

It is recognized that hepatitis C virus subtypes (1a, 1b, 2a, 2b, 2c and 3a) originated in Africa and Asia and spread worldwide exponentially during the Second World War (1940) through the transfusion of contaminated blood products, invasive medical and dental procedures, and intravenous drug use. The entry of hepatitis C virus subtypes into different regions occurred at distinct times, presenting exponential growth rates of larger or smaller spread. Our study estimated the growth and spread of the most prevalent subtypes currently circulating in São Paulo.

Methods

A total of 465 non-structural region 5B sequences of hepatitis C virus covering a 14-year time-span were used to reconstruct the population history and estimate the population dynamics and Time to Most

SUBMITTER: Nishiya AS 

PROVIDER: S-EPMC9427527 | biostudies-literature | 2015 Sep-Oct

REPOSITORIES: biostudies-literature