A 6-month trial of memantine for nystagmus and associated phenomena in oculopalatal tremor.

ABSTRACT:

Introduction

Oculopalatal tremor (OPT) is a late manifestation of a Guillain-Mollaret triangle lesion. Memantine has been shown to improve nystagmus in OPT, but its long-term efficacy and putative distinct effects on each plane of nystagmus and on associated phenomena (e.g., gravity perception) are largely unknown.

Methods

We conducted a 6-month open-label study to evaluate the effect of memantine in OPT patients. Baseline (visit 1), 2 (visit 2), and 6 months (visit 3) assessments included video-oculography, best corrected visual acuity (BCVA), visual function questionnaire (VFQ25), palatal tremor frequency, and subjective visual vertical (SVV). Memantine was titrated to 20 mg per day and stopped after 6 months.

Results

We included six patients (5 females; mean age 68

SUBMITTER: Martins AI 

PROVIDER: S-EPMC9428258 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature