Halide-Free Continuous Synthesis of Hydrophobic Ionic Liquids.

ABSTRACT: Herein, we present a novel approach for the halide-free, continuous-flow preparation of hydrophobic ionic liquids (ILs) relying on the bis(trifluoromethanesulfonyl)imide (bistriflimide, NTf₂ ^-) anion. The simple yet fast two-step synthetic route, which involves the formation of different alkyl bistriflimides (R⁴NTf₂), followed by the quaternization with an amine nucleophile, led to the desired ILs in high yields and excellent purities without any byproduct formation. The variable alkyl chain (R⁴) length and the broad range of the applicable nucleophiles (R¹R²R³N) offer considerable flexibility to the synthetic protocol. The quaternization can be performed under solvent-free conditions; moreover, the hom

SUBMITTER: Stagel K 

PROVIDER: S-EPMC9428890 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature