Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.

ABSTRACT: In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals and disease models. Such data open the way to a deeper understanding of the underlying biochemistry, related disturbances and mechanisms taking place during or prior to symptoms and tissue changes. In this work, we focus on the main preclinical ¹H, ³¹P and ¹³C MRS approaches to study brain metabolism in rodent models, with the aim of providing general experts' consensus recommendations (animal models, anesthesia, data acquisition protocols). An overview of the main practical differences in preclinical comp

SUBMITTER: Lanz B 

PROVIDER: S-EPMC9429976 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature