Dataset Information

Diagnostic Accuracy of ¹⁸F-FDG-PET/CT and ¹⁸F-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI.

ABSTRACT:

Purpose

In head and neck squamous cell carcinoma (HNSCC), the early diagnosis and efficient detection of recurrences and/or residual tumor after treatment play a very important role in patient's prognosis. Positron emission tomography (PET) using 2-deoxy-2-¹⁸F-fluoro-D-glucose (¹⁸F-FDG) has become an established method for the diagnosis of suspected recurrence in head and neck carcinomas. In particular, integrated PET/MRI imaging that provides optimal soft tissue contrast and less dental implant artifacts compared to PET/CT is an intriguing technique for the follow-up imaging of HNSCC patients. The aim of this study was to evaluate the benefit of PET/MRI compared to PET/CT in post-treatment follow-up imaging of HNSCC patients.

Methods

This retrospective observational cohort study consists of 104 patients from our center with histologically confirmed HNSCC. All patients received chemoradiotherapy (CRT) and underwent ¹⁸F-FDG-PET/CT (n = 52) or ¹⁸F-FDG-PET/MRI (n = 52) scan 12 weeks after the end of treatment. Image analysis was performed by two independent readers according to a five-point Likert scale analysis.

Results

PET/MRI was more sensitive (1.00 vs. 0.77) than PET/CT in the detection of locoregional recurrence. PET/MRI also had better negative (1.00 vs. 0.87) predictive values. AUCs for PET/MRI and PET/CT on patient-based analysis were 0.997 (95% CI 0.989-1.000) and 0.890 (95% CI 0.806-0.974), respectively. The comparison of sensitivity, AUCs, and negative predictive values revealed a statistically significant difference, p < 0.05. In PET/CT, false-negative and positive findings were observed in the more advanced disease stages, where PET/MRI performed better. Also, false-negative findings were located in the oropharyngeal, laryngeal, and nasopharyngeal regions, where PET/MRI made no false-negative interpretations.

Conclusion

Based on these results, PET/MRI might be considered the modality of choice in detecting locoregional recurrence in HNSCC patients, especially in the more advanced stages in the oral cavity, larynx, or nasopharynx.

SUBMITTER: Murtojarvi S

PROVIDER: S-EPMC9433207 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Diagnostic Accuracy of <sup>18</sup>F-FDG-PET/CT and <sup>18</sup>F-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI.

Murtojärvi Sarita S Malaspina Simona S Kinnunen Ilpo I Tuokkola Terhi T Honka Miikka-Juhani MJ Saunavaara Virva V Tolvanen Tuula T Schrey Aleksi A Kemppainen Jukka J

Contrast media & molecular imaging 20220824

<h4>Purpose</h4>In head and neck squamous cell carcinoma (HNSCC), the early diagnosis and efficient detection of recurrences and/or residual tumor after treatment play a very important role in patient's prognosis. Positron emission tomography (PET) using 2-deoxy-2-<sup>18</sup>F-fluoro-D-glucose (<sup>18</sup>F-FDG) has become an established method for the diagnosis of suspected recurrence in head and neck carcinomas. In particular, integrated PET/MRI imaging that provides optimal soft tissue co ...[more]

PMID: 36082064

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Dataset Information

Diagnostic Accuracy of ¹⁸F-FDG-PET/CT and ¹⁸F-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI.

Purpose

Methods

Results

Conclusion

Publications

Diagnostic Accuracy of <sup>18</sup>F-FDG-PET/CT and <sup>18</sup>F-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI.

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Dataset Information

Diagnostic Accuracy of 18F-FDG-PET/CT and 18F-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI.

Purpose

Methods

Results

Conclusion

Publications

Diagnostic Accuracy of <sup>18</sup>F-FDG-PET/CT and <sup>18</sup>F-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Diagnostic Accuracy of ¹⁸F-FDG-PET/CT and ¹⁸F-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI.