Effect of Intranasal Oxytocin on Resting-state Effective Connectivity in Schizophrenia.

ABSTRACT:

Objectives

Evidence from several lines of research suggests the critical role of neuropeptide oxytocin in social cognition and social behavior. Though a few studies have examined the effect of oxytocin on clinical symptoms of schizophrenia, the underlying neurobiological changes are underexamined. Hence, in this study, we examined the effect of oxytocin on the brain's effective connectivity in schizophrenia.

Methods

31 male patients with schizophrenia (SCZ) and 21 healthy male volunteers (HV) underwent resting functional magnetic resonance imaging scans with intra-nasal oxytocin (24 IU) and placebo administered in counterbalanced order. We conducted a whole-brain effective connectivity analysis using a multivariate vector autoregressive granger causality model. We performed

SUBMITTER: Korann V 

PROVIDER: S-EPMC9434443 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature