Two-dimensional Ti₃C₂T_x MXene promotes electrophysiological maturation of neural circuits.

ABSTRACT:

Background

The ideal neural interface or scaffold for stem cell therapy shall have good biocompatibility promoting survival, maturation and integration of neural stem cells (NSCs) in targeted brain regions. The unique electrical, hydrophilic and surface-modifiable properties of Ti₃C₂T_x MXene make it an attractive substrate, but little is known about how it interacts with NSCs during development and maturation.

Results

In this study, we cultured NSCs on Ti₃C₂T_x MXene and examined its effects on morphological and electrophysiological properties of NSC-derived neurons. With a combination of immunostaining and patch-clamp recording, we found that Ti₃C₂T_x MXene promotes NSCs differe

SUBMITTER: Li Y 

PROVIDER: S-EPMC9434915 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature