Biologically effective doses of 60-70Gy versus >70Gy of stereotactic body radiotherapy (SBRT) combined with chemotherapy in locally advanced pancreatic cancer: protocol of a single-centre, phase II clinical trial.

ABSTRACT:

Introduction

There is a paucity of studies about whether dose escalation of stereotactic body radiation therapy (SBRT) prolongs survival compared with de-escalation for patients with locally advanced pancreatic cancer (LAPC). Therefore, the aim of the study is to compare the survival benefits of biologically effective dose (BED₁₀, α/β=10) of 60-70 Gy with those of BED₁₀ >70 Gy.

Methods and analysis

This study is a single-centre, phase II trial. Patients with LAPC are randomly allocated to receive SBRT with BED₁₀ of 60-70 Gy or >70 Gy in 5-6 fractions combined with gemcitabine plus albumin-bound paclitaxel. The primary outcome is progression-free survival. The secondary outcomes are adverse events, local control and overall survival.

Ethics

SUBMITTER: Ye Y 

PROVIDER: S-EPMC9438046 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature