LRLoop: a method to predict feedback loops in cell-cell communication.

ABSTRACT:

Motivation

Intercellular communication (i.e. cell-cell communication) plays an essential role in multicellular organisms coordinating various biological processes. Previous studies discovered that feedback loops between two cell types are a widespread and vital signaling motif regulating development, regeneration and cancer progression. While many computational methods have been developed to predict cell-cell communication based on gene expression datasets, these methods often predict one-directional ligand-receptor interactions from sender to receiver cells and are not suitable to identify feedback loops.

Results

Here, we describe ligand-receptor loop (LRLoop), a new method for analyzing cell-cell communication based on bi-directional ligand-receptor interactions, where two

SUBMITTER: Xin Y 

PROVIDER: S-EPMC9438954 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature