Predicting recurrence and metastasis risk of endometrial carcinoma via prognostic signatures identified from multi-omics data.

ABSTRACT:

Objectives

Endometrial carcinoma (EC) is one of the three major gynecological malignancies, in which 15% - 20% patients will have recurrence and metastasis. Though there are many studies on the prognosis on this cancer, the performances of existing models evaluating the risk of its recurrence and metastasis are yet to be improved. In addition, a comprehensive multi-omics analyses on the prognostic signatures of EC are on demand. In this study, we aimed to construct a relatively stable and reliable model for predicting recurrence and metastasis of EC. This will help determine the risk level of patients and choose appropriate adjuvant therapy, thereby avoiding improper treatment, and improving the prognosis of patients.

Methods

The mRNA, microRNA (miRNA), long non-coding RNA (

SUBMITTER: Li L 

PROVIDER: S-EPMC9438970 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature