Next-generation sequencing for MRD monitoring in B-lineage malignancies: from bench to bedside.

ABSTRACT: Minimal residual disease (MRD) is considered the strongest relevant predictor of prognosis and an effective decision-making factor during the treatment of hematological malignancies. Remarkable breakthroughs brought about by new strategies, such as epigenetic therapy and chimeric antigen receptor-T (CAR-T) therapy, have led to considerably deeper responses in patients than ever, which presents difficulties with the widely applied gold-standard techniques of MRD monitoring. Urgent demands for novel approaches that are ultrasensitive and provide sufficient information have put a spotlight on high-throughput technologies. Recently, advances in methodology, represented by next-generation sequencing (NGS)-based clonality assays, have proven robust and suggestive in numerous high-quality studies

SUBMITTER: Deng X 

PROVIDER: S-EPMC9440501 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature