Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.

ABSTRACT:

Aims

Many patients are unable to achieve guideline-recommended LDL cholesterol (LDL-C) targets, despite taking maximally tolerated lipid-lowering therapy. Bempedoic acid, a competitive inhibitor of ATP citrate lyase, significantly lowers LDL-C with or without background statin therapy in diverse populations. Because pharmacodynamic interaction between statins and bempedoic acid is complex, a dose-response model was developed to predict LDL-C pharmacodynamics following administration of statins combined with bempedoic acid.

Methods and results

Bempedoic acid and statin dosing and LDL-C data were pooled from 14 phase 1-3 clinical studies. Dose-response models were developed for bempedoic acid monotherapy and bempedoic acid-statin combinations using previously published statin

SUBMITTER: Jadhav SB 

PROVIDER: S-EPMC9440868 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature