Effect of detoxification on N3 sleep correlates with brain functional but not structural changes in alcohol use disorder.

ABSTRACT:

Background

Sleep disturbances are very common in alcohol use disorder (AUD) and contribute to relapse. Detoxification appears to have limited effects on sleep problems. However, inter-individual differences and related brain mechanisms have not been closely examined.

Methods

We examined N3 sleep and the associated brain functional and structural changes in 30 AUD patients (9 Females, mean age: 42 years) undergoing a 3-week inpatient detoxification. Patients' N3 sleep, resting state functional connectivity (RSFC), grey matter volume (GMV) and negative mood were measured on week 1 and week 3.

Results

AUD patients did not show significant N3 sleep recovery after 3-weeks of detoxification. However, we observed large variability among AUD patients. Inter-individual variati

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9444901 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature