Dataset Information

Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study.

ABSTRACT:

Background and aim

We have previously reported that histamine H₁ receptor antagonists facilitate electroacupuncture (EA) analgesia in experimental animals. In this pilot study, we sought to determine whether the histamine H₁ receptor antagonist dexchlorpheniramine (DCPA) facilitates EA analgesia in healthy human subjects.

Experimental procedure

Forty healthy subjects aged 20-30 years were randomly allocated to 1 of 4 groups: (1) sham EA at acupoints Zusanli (ST36) and Yanglingquan (GB34) (sham EA; n = 10); (2) EA at ST36 and GB34 (n = 10); (3) EA at ST36 and GB34 plus low-dose DCPA (2 mg, n = 10); (4) EA at ST36 and GB34 plus high-dose DCPA (4 mg, n = 10). Before and after acupuncture treatment, pain thresholds were determined by transcutaneous electrical stimuli on the glabrous skin of the left upper arm.

Results

After the acupuncture session, subjects in the EA plus high-dose DCPA group had a significantly higher pain threshold elevation compared with the other 3 study groups. The change from baseline in pain threshold in the EA plus high-dose DCPA group was significantly greater than the change in pain threshold with EA only, indicating that DCPA 4 mg facilitated EA analgesia.

Conclusion

The results suggest that combining H₁ receptor antagonist treatment with EA appears to relieve pain to a greater extent compared with EA alone. This study is registered with ClinicalTrials.gov (https://clinicaltrials.gov/), number NCT03805035 (https://clinicaltrials.gov/ct2/show/NCT03805035).

SUBMITTER: Lee YC

PROVIDER: S-EPMC9446023 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study.

Lee Yu-Chen YC Tu Cheng-Hao CH Chung Hsin-Yi HY Luo Sih-Ting ST Chu Yu-Ting YT MacDonald Iona J IJ Kotha Peddanna P Huang Chien-Chen CC Lane Hsien-Yuan HY Lin Jaung-Geng JG Chen Yi-Hung YH

Journal of traditional and complementary medicine 20220421 5

<h4>Background and aim</h4>We have previously reported that histamine H<sub>1</sub> receptor antagonists facilitate electroacupuncture (EA) analgesia in experimental animals. In this pilot study, we sought to determine whether the histamine H<sub>1</sub> receptor antagonist dexchlorpheniramine (DCPA) facilitates EA analgesia in healthy human subjects.<h4>Experimental procedure</h4>Forty healthy subjects aged 20-30 years were randomly allocated to 1 of 4 groups: (1) sham EA at acupoints Zusanli ( ...[more]

PMID: 36081814

Similar Datasets

Project description:PurposeThe precise effects of non-steroidal anti-inflammatory drugs on the neuroendocrine hydro-electrolytic regulation are not precisely understood. The aim of this pilot study was to evaluate, in healthy subjects, the neuroendocrine response of the antidiuretic system to intravenous diclofenac infusion.MethodsFor this single-blinded, cross-over study, we recruited 12 healthy subjects (50% women). Test sessions were divided into three observation times (pre-test; test; 48 h post-test), which were repeated equally on two different occasions, with the administration of diclofenac (75 mg in saline solution 0.9% 100 cc) on 1 day, or placebo (saline solution 0.9% 100 cc) on another day. The night before the test the subjects were asked to collect a salivary cortisol and cortisone sample, which was repeated on the night of the procedure session. Serial urine and blood samples were collected on the test day (for osmolality, electrolytes, ACTH, cortisol, copeptin, MR-proADM, MR-proANP; the last three represent more stable and analytically reliable molecules than their respective active peptides). Moreover, the subjects were evaluated with the bioimpedance vector analysis (BIVA) before and after the test. Forty-eight hours after the end of the procedure urine sodium, urine potassium, urine osmolality, serum sodium and copeptin were revaluated together with BIVA.ResultsNo significant changes in circulating hormone levels were observed; anyway, 48 h after diclofenac, BIVA showed a significant water retention (p < 0.00001), especially in extracellular fluid (ECF) (16.47 ± 1.65 vs 15.67 ± 1.84, p < 0.001). Salivary cortisol and cortisone tended to increase only the night after placebo administration (p = 0.054 cortisol; p = 0.021 cortisone).ConclusionDiclofenac resulted in an increased ECF at 48 h, but this phenomenon seems to be associated with a greater renal sensibility to the action of vasopressin rather than with an increase in its secretion. Moreover, a partial inhibitory effect on cortisol secretion can be hypothesized.

Dataset Information

Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study.

Background and aim

Experimental procedure

Results

Conclusion

Publications

Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets