Antihistamine promotes electroacupuncture analgesia in healthy human subjects: A pilot study.

ABSTRACT:

Background and aim

We have previously reported that histamine H₁ receptor antagonists facilitate electroacupuncture (EA) analgesia in experimental animals. In this pilot study, we sought to determine whether the histamine H₁ receptor antagonist dexchlorpheniramine (DCPA) facilitates EA analgesia in healthy human subjects.

Experimental procedure

Forty healthy subjects aged 20-30 years were randomly allocated to 1 of 4 groups: (1) sham EA at acupoints Zusanli (ST36) and Yanglingquan (GB34) (sham EA; n = 10); (2) EA at ST36 and GB34 (n = 10); (3) EA at ST36 and GB34 plus low-dose DCPA (2 mg, n = 10); (4) EA at ST36 and GB34 plus high-dose DCPA (4 mg, n = 10). Before and after acupuncture treatment, pain thresholds were determined by transcutaneous electric

SUBMITTER: Lee YC 

PROVIDER: S-EPMC9446023 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature