Analysis of the initial dose and reduction rate of corticosteroid for ulcerative colitis in clinical practice.

ABSTRACT:

Background and aim

Trends in steroid use and the effects of the initial dose, duration of use, and tapering schedule on clinical efficacy were assessed in Japanese patients with ulcerative colitis (UC) undergoing steroid treatment.

Methods

We enrolled 191 cases with UC who underwent steroid treatment between 2006 and 2020. We assessed the difference in clinical remission rates in cases with different initial doses of steroid. Clinical factors for clinical remission at week 4 and discontinuation of corticosteroid within 12 weeks were also assessed.

Results

Clinical remission and response at week 4 were obtained in 107 (56.0%) and 58 cases (30.4%), respectively. In hospitalized patients, male sex (odds ratio [OR], 0.373; 95% confidence interval [CI], 0.146-0.956) and yo

SUBMITTER: Masuda M 

PROVIDER: S-EPMC9446402 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature