Engineering cancer cell membrane-camouflaged metal complex for efficient targeting therapy of breast cancer.

ABSTRACT:

Background

Cancer cell membrane-camouflaged nanotechnology for metal complex can enhance its biocompatibility and extend the effective circulation time in body. The ruthenium polypyridyl complex (RuPOP) has extensive antitumor activity, but it still has disadvantages such as poor biocompatibility, lack of targeting, and being easily metabolized by the organism. Cancer cell membranes retain a large number of surface antigens and tumor adhesion molecules CD47, which can be used to camouflage the metal complex and give it tumor homing ability and high biocompatibility.

Results

Therefore, this study provides an electrostatic adsorption method, which uses the electrostatic interaction of positive and negative charges between RuPOP and cell membranes to construct a cancer cell mem

SUBMITTER: Li X 

PROVIDER: S-EPMC9446690 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature