An optimized mouse model of Staphylococcus aureus infected diabetic ulcers.

ABSTRACT:

Objective

Diabetic foot infection (DFI) represents a major healthcare burden, for which treatment is challenging owing to the pathophysiological alterations intrinsic to diabetes and the alarming increase of antimicrobial resistance. Novel therapies targeting DFI are therefore a pressing research need for which proper models of disease are required.

Results

Here, we present an optimized diabetic mouse model of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, that resemble key features of DFI, such as pathogen invasion through wound bed and surrounding tissue, necrosis, persistent inflammation and impaired wound healing. Thus, in a time-efficient manner and using simple techniques, this model represents a suitable approach for studying emerging therapies ta

SUBMITTER: Mendes AI 

PROVIDER: S-EPMC9450231 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature