Disentangling the varying associations between systolic blood pressure and health outcomes in the very old: an individual patient data meta-analysis.

ABSTRACT:

Objectives

While randomized controlled trials have proven the benefits of blood pressure (BP) lowering in participating octogenarians, population-based observational studies suggest an association between low systolic blood pressure (SBP) and faster overall decline. This study investigates the effects of BP-lowering treatment, a history of cardiovascular diseases (CVD), and cognitive and physical fitness on the associations between SBP and health outcomes in the very old.

Methods

Five cohorts from the Towards Understanding Longitudinal International older People Studies (TULIPS) consortium were included in a two-step individual participant data meta-analysis (IPDMA). We pooled hazard ratios (HR) from Cox proportional-hazards models for 5-year mortality and estimates of linea

SUBMITTER: Bogaerts JMK 

PROVIDER: S-EPMC9451840 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature